Facing Chagas disease

Facing Chagas disease.

Facing Chagas' disease: trypanocidal properties of new coumarin-chalcone scaffolds.

With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, trypomastigote and amastigote stages of the Trypanosoma cruzi parasite. Cytotoxicity assays were also performed in RAW 264.7 and VERO cells. Compound 5 presented the highe...

The Centennial of the Discovery of Chagas Disease: Facing the Current Challenges

One hundred years after Carlos Chagas’ discovery [1] WHO defines Chagas disease as one of the most important infectious diseases of poverty. Beyond its biological determinants (interplays among the parasite, vector, and human), the social determinants of Chagas disease are of utmost importance; poor housing and working conditions, low salaries, and malnutrition are directly linked to Chagas dis...

[Chagas disease].

Chagas disease (human American trypanosomiasis) is a zoonose caused by the protozoan Trypanosoma cruzi. Vectors are Triatoma spp. insects. T. cruzi can also be transmitted by blood transfusion, organ transplantation, and transplacentally. Infection is generally acquired during infancy. The acute infection is rarely symptomatic and is followed by a chronic phase. Chronic infected people are asym...

Chagas' disease.

Chagas' disease is one of the most important public health problems in South America and Mexico. Migrations from rural areas into urban zones have contributed to the spread of the disease. The main targets of the disease within the body are the heart, the alimentary tract, and the nervous system. In the acute phase of the disease, the parasite responsible for the disease can be identified in th...